ABSTRACT
Introduction: Health care workers (HCWs) are among the priority groups for COVID-19 vaccination in Zimbabwe. This study was done to assess HCWs’ COVD-19 vaccine perceptions and confidence.Methodology: An analytic cross sectional study was conducted among HCWs from City of Harare health facilities. Data was collected using interviewer administered structured questionnaires which were developed using the Health Belief Model. STATA was used for data analysis. Kruskal-Wallis test and two sample Wilcoxon rank sum test were used to determine predictors of vaccine willingness.Results: A total of 513 participants were interviewed and 72·7% were females. The median age was 40 years (Q1=33, Q3=49). Nurses constituted the majority (46·8%). Social media was the leading source of COVID-19 vaccine information. The majority (92·2%) were at risk of contracting COVID-19 with 76·2% describing the risk as high. Of the participants, 20·2% were willing to receive the vaccine when it became available, 39·1% would wait and 40·7% would not at all receive the vaccine. COVID-19 vaccine perception score ranged from eight to 42. Significant predictors of willingness to receive the vaccine were sex (b= -1·689, P=0·01) and perception score (b= 0·172, P< 0·0001).Conclusion: Negative COVID-19 vaccine perceptions were demonstrated among the health care workers in the City of Harare and these were associated with unwillingness to be vaccinated. Targeted health education and COVID-19 vaccine awareness needs to be conducted among HCWs. Tailored strategies to address vaccine concerns raised in the study will decrease vaccine hesitancy.Funding: None to declare. Declaration of Interest: None to declare.
Subject(s)
COVID-19ABSTRACT
Zimbabwe reported its first case of SARS-Cov-2 infection in March 2020, and case numbers increased to more than 8,099 to 16th October 2020. An understanding of the SARS-Cov-2 outbreak in Zimbabwe will assist in the implementation of effective public health interventions to control transmission. Nasopharyngeal samples from 92,299 suspected and confirmed COVID-19 cases reported in Zimbabwe between 20 March and 16 October 2020 were obtained. Available demographic data associated with those cases identified as positive (8,099) were analysed to describe the national breakdown of positive cases over time in more detail (geographical location, sex, age and travel history). The whole genome sequence (WGS) of one hundred SARS-CoV-2-positive samples from the first 120 days of the epidemic in Zimbabwe was determined to identify their relationship to one another and WGS from global samples. Overall, a greater proportion of infections were in males (55.5%) than females (44.85%), although in older age groups more females were affected than males. Most COVID-19 cases (57 %) were in the 20-40 age group. Eight lineages, from at least 25 separate introductions into the region were found using comparative genomics. Of these, 95% had the D614G mutation on the spike protein which was associated with higher transmissibility than the ancestral strain. Early introductions and spread of SARS-CoV-2 were predominantly associated with genomes common in Europe and the United States of America (USA), and few common in Asia at this time. As the pandemic evolved, travel-associated cases from South Africa and other neighbouring countries were also recorded. Transmission within quarantine centres occurred when travelling nationals returning to Zimbabwe. International and regional migration followed by local transmission were identified as accounting for the development of the SARS-CoV-2 epidemic in Zimbabwe. Based on this, rapid implementation of public health interventions are critical to reduce local transmission of SARS-CoV-2. Impact of the predominant G614 strain on severity of symptoms in COVID-19 cases needs further investigation.